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对近五年PubMed收录的环境因素影响导致尿道下裂形成的原始研究性文章展开综述。搜索2007至2012年英文,标题中含有“hypospadias”的原始研究性文章,排除综述、评论及病例报道,明确提出对具体环境因素进行研究的原始研究性文章达到入选标准。25篇文章达到入选标准,对其分类汇总,从化学物质、父母特性、营养及激素水平四方面对其展开综述。尽管已经证明一些环境因素与尿道下裂形成有联系,但仍缺乏权威性研究结果,仍需进一步研究。
This review summarizes the original research articles that led to the formation of hypospadias due to the influence of environmental factors included in PubMed in the past five years. Search for English articles from 2007 to 2012, the original research article containing “hypospadias” in the title, excluding reviews, reviews and case reports, and clearly put forward that the original research articles on specific environmental factors met the inclusion criteria. Twenty-five articles met the inclusion criteria and were grouped into categories to review them in terms of chemical substances, parental characteristics, nutrition and hormone levels. Although some environmental factors have been proved to be associated with the formation of hypospadias, the lack of authoritative research results still need further study.