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目的分析原发性乳腺淋巴瘤(PBL)的临床病理特点、诊断、治疗及预后。方法回顾分析2000年12月-2011年10月收治的19例PBL患者的临床资料和治疗随访情况。结果 19例PBL患者均为女性,年龄34～72岁。根据Ann Arbor临床分期,Ⅰ期患者9例,Ⅱ期7例,Ⅲ期3例,而病理类型以弥漫大B淋巴瘤为主(13/19)。全部患者随访时间为6～113个月,中位随访时间为45个月,5年生存率为36.8%。结论 PBL其预后与病理类型、分期及治疗方式有关。手术联合放射化学疗法为主要治疗方式,腋窝淋巴结清扫有一定的意义,但对PBL预后的影响值得商榷。此外,PBL易出现中枢神经系统转移,应定期复查。
Objective To analyze the clinicopathological features, diagnosis, treatment and prognosis of primary breast lymphoma (PBL). Methods The clinical data and treatment follow-up of 19 patients with PBL admitted from December 2000 to October 2011 were retrospectively analyzed. Results 19 cases of PBL patients were female, aged 34 to 72 years. According to Ann Arbor clinical stage, 9 cases were stage Ⅰ, 7 cases were stage Ⅱ and 3 cases were stage Ⅲ, while the pathological type was diffuse large B lymphoma (13/19). All patients were followed up for 6 to 113 months. The median follow-up time was 45 months and the 5-year survival rate was 36.8%. Conclusion The prognosis of PBL is related to the pathological type, stage and treatment. Surgery combined with radiotherapy as the main treatment, axillary lymph node dissection has some significance, but the prognosis of PBL is debatable. In addition, PBL prone to central nervous system metastasis, should be regularly reviewed.