肝细胞癌(HCC)是临床上最常见的恶性肿瘤之一,严重威胁人类的健康和生命。伴随分子生物学的发展人们逐渐认识到HCC的发生、发展和转移与细胞信号传导通路、新生血管增生异常等密切相关。这也正是进行分子靶向治疗的理论基础及潜在靶点。近年来,分子靶向药物治疗已成为HCC治疗的研究热点,国内外许多临床试验已经取得进展。 Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in clinic, which seriously threatens human health and life. With the development of molecular biology, people have come to realize that the occurrence, development and metastasis of HCC are closely related to cell signal transduction pathway and neovascular dysplasia. This is also the theoretical basis for molecular targeted therapy and potential targets. In recent years, molecular targeted drug therapy has become a hot research topic in the treatment of HCC. Many clinical trials at home and abroad have made some progress.