黑色素瘤原发病变90%以上发生于皮肤,多见于足底、小腿、指(趾)间、手掌、指甲下、甲沟、头皮、颈部和外阴部等,也可发生在躯干皮肤。另外也可发生在直肠、肛门、食管和眼内,甚至小肠等内脏器官。如右图:黑色素瘤临床表现主要为迅速增大的黑色素结节。初起可于正常皮肤发生黑色素沉着,或者色素 More than 90% of primary melanoma lesions occur in the skin, more common in the plantar, calf, fingers (toes), palms, under the nails, a ditch, scalp, neck and vulva, etc., can also occur in the trunk skin. It can also occur in the rectum, anus, esophagus and eyes, and even the small intestine and other internal organs. As shown on the right: The main clinical manifestations of melanoma are rapidly increasing melanin nodules. In the beginning, melanin pigmentation or pigmentation may occur in normal skin.