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通过壳聚糖与聚乙烯醇共混,用戊二醛作交联剂制备了聚乙烯醇/壳聚糖凝胶,并考察了不同质量比、交联剂浓度以及温度对凝胶的硬度和溶胀性能的影响。结果表明:随着聚乙烯醇与壳聚糖的质量比、交联剂浓度的增大,凝胶的硬度增大而溶胀性能减小。随着成胶温度的升高,凝胶的硬度和溶胀性能均先增大后减小。在此基础上,通过两种方法将银粒子分散到凝胶中:(1)在成胶过程中加入硝酸银,成胶后用还原剂硼氢化钠还原;(2)制成凝胶以后,将凝胶依次浸泡在硝酸银和硼氢化钠溶液中。通过XRD和SEM表征,说明两种方法均能将银粒子均匀分散在凝胶中,从而表明壳聚糖凝胶可以作为金属纳米粒子的载体,这将在生物医学方面具有良好的应用前景。
Polyvinyl alcohol / chitosan gel was prepared by blending chitosan with polyvinyl alcohol and using glutaraldehyde as crosslinking agent. The effects of different mass ratio, concentration of crosslinking agent and temperature on the hardness and Effect of swelling properties. The results showed that with the mass ratio of polyvinyl alcohol to chitosan and the concentration of crosslinking agent increasing, the hardness of gel increased and the swelling property decreased. With the increase of gelation temperature, the hardness and swelling properties of gels first increase and then decrease. On this basis, the silver particles are dispersed into the gel by two methods: (1) silver nitrate is added into the gel during the gelatinization, and the silver particles are reduced with the sodium borohydride reductant; (2) after the gel is formed, The gel is sequentially soaked in silver nitrate and sodium borohydride solution. The results of XRD and SEM indicate that the silver nanoparticles can be uniformly dispersed in the gel by both methods, indicating that the chitosan gel can be used as the carrier of the metal nanoparticles. This method has a promising prospect in biomedicine.