胰岛素生物合成前身—胰岛素原的发现,使肽类激素生物合成的研究进入了一个新阶段.胰岛素原是一条多肽链,其中的胰岛素A及B链被一连接肽相连.硷性二肽,精-精,赖-精分别为连接肽的两个末端.胰岛素原C肽是连接肽减去二个硷性二肽.特别值得注意的是,一种肽类激素是由它的单链前身通过选择性蛋白水解而形成.曾设想,胰岛素原转变成胰岛素,可能是在与胰蛋白酶及羧肽酶B性质相类似的酶的联合作用下完成的.曾经观察到,胰岛素原可在胰蛋白酶作用下,迅速转变成去丙氨敢胰岛素.虽然哺乳类动物的天然胰岛素 The discovery of proinsulin, the predecessor of insulin biosynthesis, has led to a new phase in the study of peptide hormone biosynthesis, a polypeptide chain in which the insulin A and B chains are linked by a linker peptide, - Essence, Leu-Essence are the two termini of the linker peptide, respectively, and the proinsulin C peptide is the linker minus the two basic dipeptides. Of particular note is that a peptide hormone is passed by its single- Selective proteolysis.It has been envisaged that the conversion of proinsulin into insulin may be done in combination with an enzyme analogous to the properties of trypsin and carboxypeptidase B. It has been observed that proinsulin can be activated by trypsin Under the rapid transformation into propranolol, although insulin is a natural insulin for mammals