纤溶和抗凝疗法是指应用一些能增强血液和组织中纤维蛋白溶解能力、抑制血小板粘聚及阻止纤维蛋白(血凝块)形成的药物来进行治疗疾病的一种方法,长期来有效地使用于一些血管疾病的防治中。但在皮肤科领域中的应用还是一个比较新的手段。自Cunliffe等于1968年发现某些皮肤血管炎患者血液和组织纤溶活性降低,并应用纤溶药物成功地进行治疗以来,关于这方面的研究逐渐引起了重视。现在,不仅已证明此种疗法对一些皮肤血管炎有肯定效果,而且对其它以皮肤血管病变为主的疾病如白塞氏病、雷诺氏现象(原发性或继发于系统性硬皮病的)、血栓性静脉炎、系统性红斑狼疮 Fibrinolytic and anticoagulant therapy refers to the use of a number of drugs that enhance fibrinolytic activity in blood and tissues, inhibit platelet aggregation, and prevent the formation of fibrin (blood clots) to treat diseases. Effectively Used in the prevention and treatment of some vascular diseases. However, the application in the field of dermatology is still a relatively new means. Since Cunliffe was found to have decreased the fibrinolytic activity of blood and tissue in some patients with cutaneous vasculitis in 1968 and has been successfully treated with fibrinolytic drugs, more and more attention has been paid to this aspect. Now, not only has this treatment been shown to have some positive effects on cutaneous vasculitis, but also on other diseases predominant of cutaneous vascular disease such as Behcet’s disease, Raynaud’s phenomenon (primary or secondary to systemic scleroderma ), Thrombophlebitis, systemic lupus erythematosus