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目的探讨吡格列酮对2型糖尿病周围神经病变患者血尿酸变化的影响。方法收集2014年7月—2015年7月在南通市通州区第三人民医院住院并确诊患有糖尿病周围神经病变的患者80例,随机分为对照组和观察组各40例,两组患者均进行饮食控制结合运动疗法等一般治疗方式。对照组给予二甲双胍治疗,0.5 g/次,每日3次。观察组在对照组的基础上给予吡格列酮治疗,吡格列酮剂量为15 mg/次,每日1次。两组服药时间均为2个月。结果两组空腹血糖及餐后2 h血糖浓度经治疗后均降低,观察组低于对照组(P<0.05);对照组治疗前后血尿酸差异无明显变化(P>0.05),观察组治疗后血尿酸浓度显著降低(P<0.05);两组治疗后CSS评分均低于治疗前评分(P<0.05);治疗后观察组评分低于对照组(P<0.05)。结论吡格列酮联合二甲双胍对治疗2型糖尿病周围神经病变有一定疗效,可降低2型糖尿病周围神经病变患者血尿酸水平。
Objective To investigate the effect of pioglitazone on serum uric acid in type 2 diabetic peripheral neuropathy patients. Methods Totally 80 patients were hospitalized in the Third People’s Hospital of Tongzhou District of Nantong City from July 2014 to July 2015 and were randomly divided into control group and observation group of 40 patients. Dietary control combined with exercise therapy and other general treatment. The control group was treated with metformin, 0.5 g / time, 3 times a day. The observation group was given pioglitazone on the basis of the control group, and the dosage of pioglitazone was 15 mg once daily. Both groups took 2 months. Results Both fasting blood glucose and postprandial 2-h blood glucose levels were lower after treatment in the observation group than in the control group (P <0.05). There was no significant difference in serum uric acid between the two groups before and after treatment (P> 0.05) The serum uric acid concentration was significantly lower (P <0.05). The CSS scores of both groups were lower than those before treatment (P <0.05). After treatment, the score of the observation group was lower than that of the control group (P <0.05). Conclusion Pioglitazone combined with metformin has some curative effect on the peripheral neuropathy of type 2 diabetes mellitus, which can reduce the level of serum uric acid in patients with type 2 diabetic peripheral neuropathy.