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目的:观察中药复方治疗分化型甲状腺癌术后患者血清甲状腺球蛋白(TG)浓度和甲状腺球蛋白抗体(TG-Ab)浓度的变化。方法:将纳入观察的96例患者随机分成2组各48例,观察组采用中药联合左旋甲状腺素片(L-T4)进行治疗,对照组单纯采用L-T4治疗,治疗周期为3月。治疗开始时检测外周血TG浓度、TG-Ab浓度及安全性指标肝肾功能、甲状腺功能,治疗结束后再次检测外周血TG、TG-Ab浓度及安全性指标游离三碘甲腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4)、门冬氨酸转移酶(AST)、谷丙转氨酶(ALT)、血清肌酐(SCr)。比较TG及TG-Ab浓度的变化。结果:治疗后,观察组外周血、TG-Ab与对照组比较,差异有统计学意义(P<0.01)。治疗后,观察组全切患者TG对照组比较,差异有统计学意义(P<0.01);观察组次全切、全切患者TG-Ab分别与对照组比较,差异均有统计学意义(P<0.01)。不良反应情况,2组治疗前后肝肾功能指标ALT、AST、SCr,甲状腺功能指标T4、T3、FT4、FT3等与治疗前比较,差异无统计学意义(P>0.05);治疗后,2组ALT、AST、SCr、T4、T3、FT4、FT3比较,差异均无统计学意义(P>0.05)。提示2组治疗方法具有一定的安全性。结论:中药复方治疗分化型甲状腺癌术后患者,能改善患者TG和TG-Ab情况,且具有一定的安全性。
Objective: To observe the changes of serum thyroglobulin (TG) concentration and thyroglobulin antibody (TG-Ab) concentration in patients with differentiated thyroid cancer treated by compound traditional Chinese medicine. Methods: The 96 patients included in the study were randomly divided into two groups of 48 patients. The observation group was treated with L-T4 and the control group was treated with L-T4 alone. The treatment period was March. Peripheral blood TG concentration, TG-Ab concentration and safety index, liver and kidney function, thyroid function were measured at the beginning of treatment. Concentration of TG and TG-Ab and safety index in peripheral blood were measured again after treatment. Free triiodothyronine ( FT3, FT4, AST, ALT and SCr. Changes in TG and TG-Ab concentrations were compared. Results: After treatment, there was significant difference between the observation group and the control group (P <0.01). After treatment, there was significant difference between the TG control group and the control group (P <0.01). TG-Ab of sub-total and complete resection in the observation group were significantly different from the control group (P <0.01). There was no significant difference in the ALT, AST, SCr, thyroid function indexes T4, T3, FT4, FT3 before and after treatment between the two groups before treatment (P> 0.05) ALT, AST, SCr, T4, T3, FT4, FT3, the difference was not statistically significant (P> 0.05). Tip 2 treatment has some safety. Conclusion: The traditional Chinese medicine compound for the treatment of differentiated thyroid cancer patients can improve the TG and TG-Ab patients, and has some safety.