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目的：探讨茶多酚在治疗慢性肾功能衰竭（ＣＲＦ）中抗脂质过氧化及改善肾功能的作用。方法：观察３１例ＣＲＦ患者（治疗组）用海南省茶多酚（ＴＰ）治疗前及治疗后３个月的红细胞超氧化物歧化酶（ＳＯＤ）、还原型谷胱甘肽（ＧＳＨ）、血浆丙二醛（ＭＤＡ），血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ），血尿素氮（ＢＵＮ）和血肌酐（ＳＣｒ）含量变化。另以未经ＴＰ治疗的２０例ＣＲＦ患者为对照组，并与８９例健康成人的ＳＯＤ、ＧＳＨ和ＭＤＡ作比较。结果：治疗组及对照组ＣＲＦ患者ＳＯＤ活性明显低于健康成人（Ｐ均＜０．０１），ＭＤＡ及ＧＳＨ高于健康成人（Ｐ均＜０．０５）；治疗后治疗组ＳＯＤ活性明显升高，ＭＤＡ、ＴＣ、ＴＧ、ＢＵＮ和ＳＣｒ均有降低，与对照组比较差异均显著（Ｐ均＜０．０５）。肾功能改善总有效率前者为６７．７４％，后者为３０．００％。结论：ＣＲＦ患者确实存在ＳＯＤ活性降低及脂质过氧化损伤，海南省茶多酚能有效对抗脂质过氧化，提高氧化酶ＳＯＤ活性，改善ＣＲＦ患者肾功能。
Objective: To investigate the role of tea polyphenols in the treatment of chronic renal failure (CRF) in anti-lipid peroxidation and improve renal function. Methods: Totally 31 patients with CRF (treatment group) were treated with TP (Hainan Province) before treatment and 3 months after treatment. The levels of erythrocyte superoxide dismutase (SOD), reduced glutathione (GSH), plasma (MDA), serum total cholesterol (TC), triglyceride (TG), blood urea nitrogen (BUN) and serum creatinine (SCr) The other 20 untreated CRF patients were compared with the control group and compared with the SOD, GSH and MDA of 89 healthy adults. Results: The SOD activity of CRF patients in treatment group and control group was significantly lower than that in healthy adults (P <0.01), MDA and GSH were higher than those in healthy adults (P <0.05), and the activity of SOD in treatment group was significantly higher , MDA, TC, TG, BUN and SCr decreased significantly compared with the control group (all P <0.05). The total effective rate of renal function improvement was 67.74%, the latter was 30.00%. CONCLUSIONS: Decreased SOD activity and lipid peroxidation damage do exist in CRF patients. Tea polyphenols in Hainan Province can effectively counteract lipid peroxidation, increase SOD activity and improve renal function in patients with CRF.