论文部分内容阅读
目的观察早期应用精氨酸血管加压素(arginine vasopressin,AVP)维持血压对非控制出血性休克大鼠器官血流灌注和功能的影响。方法 96只SD大鼠分为对照组(低压复苏)和AVP组(AVP 5×10-4 U·m L-1)。制备非控制出血性休克模型,观察早期(模拟院前救治阶段)应用AVP维持血压(50 mm Hg,3 h)对休克动物的心功能指标和组织氧供/氧耗、肝/肾血流量、肝/肾功能及其线粒体功能的影响。结果早期应用AVP维持血压可明显改善心功能指标,提高心输出量和增加组织氧供/氧耗;同时AVP治疗也明显提高了肝血流量、改善肝线粒体功能,并明显降低了休克后升高的肝功能指标AST和ALT,其效果明显优于对照组。但AVP组的肾血流量低于对照组,且2组间肾线粒体功能和肾功能指标(BUN和Scr)差异无统计学意义。结论早期应用AVP可更有效的改善心功能、改善重要器官的血流灌注和肝线粒体功能,发挥抗休克作用。但AVP对肾功能的影响需进一步研究。
Objective To observe the effect of early application of arginine vasopressin (AVP) on blood perfusion and function in non-controlled hemorrhagic shock rats. Methods 96 SD rats were divided into control group (low pressure resuscitation) and AVP group (AVP 5 × 10-4 U · m L-1). The model of uncontrolled hemorrhagic shock was established and the cardiac function indexes and oxygen supply and oxygen consumption, liver / kidney blood flow, Liver / kidney function and its mitochondrial function. Results Early use of AVP to maintain blood pressure can significantly improve cardiac function, improve cardiac output and increase tissue oxygen supply / oxygen consumption. At the same time AVP treatment also significantly improved hepatic blood flow, improved hepatic mitochondrial function, and significantly decreased after shock The liver function indicators AST and ALT, the effect was significantly better than the control group. However, the renal blood flow in AVP group was lower than that in control group, and there was no significant difference in renal mitochondrial function and renal function index (BUN and Scr) between two groups. Conclusion Early application of AVP can improve cardiac function more effectively, improve blood flow perfusion and hepatic mitochondrial function of vital organs and exert anti-shock effect. However, the impact of AVP on renal function needs further study.