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目的:应用骨生物力学和组织形态学,研究伊班膦酸钠在糖皮质激素诱导的骨质疏松症家兔模型中的治疗作用。方法:50只家兔随机分为:对照组1和2(注射生理盐水)、模型组1(注射地塞米松,连续6周)、模型组2(注射地塞米松,连续12周)和治疗组(注射地塞米松6周后,注射1次伊班膦酸钠)。6周后将对照组1和模型组1家兔处死;12周后将其他组家兔处死。结果:组织形态学和骨生物力学结果显示骨质疏松症家兔模型成功建立。12周时,治疗组家兔腰椎压缩和股骨3点弯曲最大负荷及肱骨抗扭转最大扭矩比模型组2分别提高了54.36%,21.38%和105.75%(P<0.05),骨质疏松症形态学改变得到明显改善,骨小梁排列较密集,连接增多,成骨活跃,医学图像分析腰椎和股骨颈面密度增加(P<0.05)。结论:伊班膦酸钠可有效治疗糖皮质激素引起的骨质疏松症,提高模型家兔的骨生物力学特性,改善骨小梁的组织结构。
OBJECTIVE: To study the therapeutic effect of ibandronate sodium in glucocorticoid-induced osteoporosis rabbits using bone biomechanics and histomorphology. Methods: Fifty rabbits were randomly divided into control group 1 and 2 (saline injection), model group 1 (dexamethasone for 6 weeks), model group 2 (dexamethasone for 12 weeks) and treatment Group (dexamethasone 6 weeks after injection of ibuprofen sodium). After 6 weeks, rabbits in control group 1 and model group were sacrificed; rabbits in other groups were sacrificed after 12 weeks. RESULTS: Histomorphology and biomechanics results showed that the rabbit model of osteoporosis was successfully established. At 12 weeks, the maximum load of lumbar compression and 3-point bending of the femur and torsion torque of the humerus in treatment group were increased by 54.36%, 21.38% and 105.75% (P <0.05), respectively, compared with model group 2 Changes were significantly improved, trabecular arrangement more dense, more connections, active osteogenesis, medical image analysis of lumbar and femoral neck density (P <0.05). CONCLUSION: Ibandronate can effectively treat glucocorticoid-induced osteoporosis, improve the biomechanical properties of the model rabbits and improve the structure of trabecular bone.