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目的:观察肺岩宁方对晚期非小细胞肺癌患者血清CEA、CYFRA21-1水平,免疫功能以及中医证候的影响。方法:50例确诊为Ⅲa、Ⅲb、Ⅳ期非小细胞肺癌患者,中医辨证为精气亏虚型,中药肺岩宁方治疗2个月。结果:肺岩宁方可以降低血清CEA和CYFRA21-1水平,提高晚期非小细胞肺癌患者CD3、CD4、CD4/CD8细胞水平,降低CD8细胞水平。患者神疲乏力、动则气喘、腰膝酸痛、少气懒言等症状明显改善,卡氏评分上升6.06。结论:肺岩宁方具有明显改善晚期肺癌患者的生活质量,显著提高患者的免疫功能的作用。
Objective: To observe the effects of Feiyanning on serum CEA, CYFRA21-1 levels, immune function and TCM syndromes in patients with advanced non-small cell lung cancer. Methods: 50 patients diagnosed as stage Ⅲ a, Ⅲ b, Ⅳ non-small cell lung cancer patients, syndrome differentiation for the essence of Qi deficiency type, traditional Chinese medicine lung Yan Ning for 2 months. Results: Feiyanning Decoction can reduce the levels of serum CEA and CYFRA21-1, increase the levels of CD3, CD4, CD4 / CD8 and decrease the level of CD8 in patients with advanced non-small cell lung cancer. Patients with Shenpi fatigue, moving the asthma, waist and knee pain, lack of breath lazy words and other symptoms improved significantly, the card’s score rose 6.06. Conclusion: Feiyanningfang can significantly improve the quality of life of patients with advanced lung cancer and significantly improve the immune function of patients.