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目的:研究HIV/HCV共感染患者血清中HCV病毒载量、CD4+T细胞计数及细胞因子等变化。方法:选取共感染者66例,HCV、HIV单独感染者38、34例和健康者33例。PCR检测HCV病毒载量;流式细胞仪检测CD4+T细胞计数;ELISA法检测IFN-γ和IL-10含量。结果:与HCV组相比,共感染组HCV病毒载量明显增高;CD4+T细胞计数明显降低;IFN-γ水平下降(P<0.01)。结论:共感染可加速HCV复制、降低IFN-γ水平;HCV病毒载量增高与CD4+T细胞数量无关。
Objective: To study the changes of serum HCV viral load, CD4 + T cell count and cytokines in HIV / HCV co-infected patients. Methods: Sixty-six co-infected patients, 38,34 HCV and HIV-infected individuals and 33 healthy controls were selected. PCR detection of HCV viral load; CD4 + T cell count by flow cytometry; ELISA assay IFN-γ and IL-10 content. Results: Compared with the HCV group, the viral load in the co-infected group was significantly increased; the CD4 + T cell count was significantly decreased; and the IFN-γ level was decreased (P <0.01). CONCLUSION: Co-infection can accelerate HCV replication and decrease IFN-γ level. The increase of HCV viral load has nothing to do with the number of CD4 + T cells.