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p53基因突变是与人类肿瘤有关的最常见的基因异常,p53蛋白是突变型p53基因的表达产物。本研究应用免疫组化技术对129例非霍奇金淋巴瘤和50例反应性增生淋巴结病理标本进行p53蛋白表达检测,探讨p53蛋白与非霍奇金淋巴瘤的病理诊断、恶性程度及临床的相关性。1材料与方法1.1材料?
p53 mutations are the most common genetic abnormalities associated with human tumors and p53 proteins are the expression products of mutant p53 genes. In this study, p53 protein was detected by immunohistochemistry in 129 cases of non-Hodgkin’s lymphoma and 50 cases of reactive hyperplasia lymph node. The pathological diagnosis, malignancy and clinical status of p53 protein and non-Hodgkin’s lymphoma were investigated. Correlation. 1 Materials and Methods 1.1 Materials?