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目的评估绒毛膜促性腺激素注射日子宫内膜厚度与体外授精-胚胎移植妊娠结局之间的相关性。方法回顾性分析1737个IVF-ET周期,按照HCG日子宫内膜厚度分为3组(A组:<8mm;B组:8-14mm;C组:>14mm),比较3组胚胎种植率、临床妊娠率及流产率等妊娠结局的差异。结果 3组的胚胎种植率分别为:16.0%、34.1%、18.6%,B组胚胎种植率虽高于A组和C组,但3组间无统计学差异(P>0.05);3组的临床妊娠率分别为:28.6%、46.7%、31.4%,B组临床妊娠率明显高于其他两组,有统计学差异(P<0.05),A组和C组临床妊娠率无统计学差异(P>0.05);3组的流产率分别为:15.9%、14.5%、14.7%,无统计学差异(P>0.05);结论注射HCG日子宫内膜的厚度影响了IVF-ET的治疗结局,厚度处于8-14 mm时将预示更好的临床结局。
Objective To evaluate the correlation between endometrial thickness at the injection of chorionic gonadotrophin and pregnancy outcome in vitro fertilization-embryo transfer. Methods A total of 1737 IVF-ET cycles were retrospectively analyzed. The endometrial thickness was divided into three groups (group A: <8 mm; group B: 8-14 mm; group C:> 14 mm) Clinical pregnancy rates and abortion rates and other pregnancy outcomes differences. Results The embryo implantation rates of the three groups were 16.0%, 34.1% and 18.6% respectively. Although the implantation rate of embryos in group B was higher than that of group A and C, there was no significant difference among the three groups (P> 0.05) The clinical pregnancy rates were 28.6%, 46.7% and 31.4% respectively. The clinical pregnancy rates in group B were significantly higher than those in the other two groups (P <0.05), but there was no significant difference in clinical pregnancy rates between groups A and C (P> 0.05). The miscarriage rates of the three groups were 15.9%, 14.5% and 14.7% respectively (P> 0.05). Conclusion The thickness of endometrium injected on HCG affected the therapeutic outcome of IVF-ET, A thickness of 8-14 mm will indicate a better clinical outcome.