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我们采用硝苯吡啶治疗小儿腹痛20例,取得满意效果。患儿平均年龄6岁。胃肠痉挛20例,急性胃肠炎6例。排除外科疾患并测血压、心率后,立即舌下含服硝苯吡啶0.6mg/kg。服药后注意观察腹痛停止时间、皮肤颜色、血压和心率。结果服药后肠痉挛患儿均显效(10分钟内腹痛止);急性胃肠炎患儿显效4例,有效(服药后15分钟内腹痛止)1例,无效l例。用药前后血压无显著差异,心率有所减慢。 讨论:硝苯吡啶治疗小儿腹痛的机理是,通过阻滞平滑肌细胞摄取钙离子,降低兴奋—收缩偶联中ATP酶的活性,使肠蠕动减慢。一般舌下用药2～3分钟起效,作用维持时间达5～6小时。本组结果显示,其治疗肠痉挛疗效好,总有效率为96％。因此认为,该药口服含化无异味,应用剂量小,疗效好,见效快,较适用于门诊患儿。本组5％的患儿服药
We use nifedipine treatment of abdominal pain in children 20 cases, and achieved satisfactory results. The average age of children 6 years old. Gastrointestinal cramps in 20 cases, 6 cases of acute gastroenteritis. Exclude surgical conditions and measure blood pressure, heart rate, immediately sublingual nifedipine 0.6mg / kg. After taking medication to observe abdominal pain stop time, skin color, blood pressure and heart rate. Results Children with intestinal spasm after taking medication were markedly effective (abdominal pain only within 10 minutes); 4 cases of children with acute gastroenteritis were effective and 1 case of effective (abdominal pain within 15 minutes after taking medicine) was ineffective. No significant difference in blood pressure before and after treatment, heart rate has slowed down. Discussion: The mechanism of nifedipine treatment of abdominal pain in children is to slow the bowel motility by blocking the uptake of calcium by smooth muscle cells and reducing the activity of ATPase in excitatory-contractile coupling. General sublingual medication 2 to 3 minutes of onset, the role of maintaining time of 5 to 6 hours. The results of this group show that the treatment of intestinal spasm good effect, the total effective rate was 96%. Therefore, the drug containing oral odor, the application of small doses, good effect, quick, more suitable for out-patient children. This group of 5% of children taking medicine