论文部分内容阅读
目的通过对类风湿关节炎(RA)患者血清中人类软骨糖蛋白39(HCgp-39)水平的检测,研究其与RA疾病活动的相关性及早期诊断意义。方法采集84例RA患者和40例健康人血清标本,采用ELISA方法检测2组血清中HCgp-39含量、免疫速率散射比浊法测类风湿因子(RF)C反应蛋白含量,并进行比较分析。结果 RA患者血清HCgp-39水平明显高于其他非RA患者和健康人,且与血沉、C反应蛋白,IgM型类风湿因子水平等活动性指标高度相关。结论 HCgp-39水平与RA疾病活动性相关,监测其浓度变化有助于发现骨关节破坏和疾病的早期诊断。
OBJECTIVE: To investigate the correlation between the level of HCgp-39 in the serum of patients with rheumatoid arthritis (RA) and the activity of RA and the significance of its early diagnosis. Methods Serum samples from 84 patients with RA and 40 healthy subjects were collected. The levels of HCgp-39 in the two groups were detected by ELISA, and the content of rheumatoid factor (RF) C-reactive protein in the two groups were measured and compared by ELISA. Results The serum level of HCgp-39 in patients with RA was significantly higher than those in other non-RA patients and healthy subjects, and was highly correlated with activity indexes such as erythrocyte sedimentation rate, C-reactive protein and rheumatoid factor IgM. Conclusions The level of HCgp-39 is correlated with the activity of RA. Monitoring the changes of HCgp-39 concentration may help to find the early diagnosis of bone and joint destruction and disease.