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本文应用免疫组化法研究了大肠癌和大肠腺癌组织中ｃ－ｆｏｓ、ＴＧＦ－α表达的意义。３２例大肠癌ｃ－ｆｏｓ、ＴＧＦ－α阳性病例率为５０％和５９．４％，４０例腺瘤则分别为２７．５％和５５％；高分化腺癌ｃ－ｆｏｓ阳性病例率明显低于低分化腺癌、粘液腺癌和未分化癌；ＡＴＰ（０～＋）级腺瘤ｃ－ｆｏｓ、ＴＧＦ－α阳性病例率明显低于ＡＴＰ（～）级腺瘤；淋巴结转移大肠癌ｃ－ｆｏｓ、ＴＧＦ－α阳性病例率高于淋巴结未转移的大肠癌，但无统计学意义。提示ｃ－ｆｏｓ、ＴＧＦ－α可能与大肠癌发生发展、生物学行为及预后有密切关系。
The significance of c-fos and TGF-α expression in colorectal cancer and colorectal adenocarcinoma was studied using immunohistochemistry. The positive rate of c-fos and TGF-α was 50% and 59.4% in 32 cases of colorectal cancer, 27.5% and 55% in 40 cases, and the rate of c-fos positive cases in poorly differentiated adenocarcinoma was obviously low. In poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and undifferentiated carcinoma, the positive rates of c-fos and TGF-α in ATP (0～+) grade adenomas were significantly lower than those in ATP (~) grade adenomas; lymph node metastasis in colorectal cancer c- The positive rate of fos and TGF-α was higher than that of metastasized colorectal cancer, but it was not statistically significant. It is suggested that c-fos and TGF-α may be closely related to the occurrence, development, biological behavior and prognosis of colorectal cancer.