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[目的]观察加减补中益气汤联合奥沙利铂、替吉奥(SOX)方案治疗晚期胃癌患者的临床疗效。[方法]采用随机、对照方法。将53例晚期胃癌患者随机分为两组,对照组26例采用SOX方案化疗,治疗组27例在对照组治疗的基础上同时口服加减补中益气汤,自化疗前3d开始服用,1剂/d,分2次温服,连续服用至化疗结束后3d。两组均以21d为1周期,完成2个周期后评价近期疗效、中医证候疗效、毒副反应等。[结果]两组近期疗效总有效率比较无明显差异(P>0.05)。在中医证候疗效、体力状况疗效方面,治疗组治疗后指标优于对照组(P<0.01);治疗组的白细胞减少、消化道反应、周围神经毒性程度优于对照组(P<0.05)。[结论]加减补中益气汤联合SOX方案治疗晚期胃癌可以改善患者的中医症候及体力状况,降低化疗毒副反应,优于单纯SOX方案化疗。
[Objective] To observe the clinical effects of Bu Zhong Yi Qi Decoction combined with oxaliplatin and tioguan (SOX) regimen in patients with advanced gastric cancer. [Methods] A randomized, controlled method was used. 53 patients with advanced gastric cancer were randomly divided into two groups, control group, 26 patients with SOX chemotherapy, the treatment group 27 patients in the control group based on the same time oral administration of Bu Zhong Yi Qi Tang, since the beginning of 3 days before chemotherapy, 1 Agent / d, sub-2 warm clothes, continuous use to 3d after chemotherapy. Two groups were 21d for a cycle, completed two cycles after the evaluation of the recent efficacy, efficacy of traditional Chinese medicine syndrome, side effects. [Results] The total effective rate of the two groups had no significant difference (P> 0.05). Compared with the control group (P <0.01), the treatment group had better leukopenia, gastrointestinal reaction and peripheral neurotoxicity than the control group (P <0.05). [Conclusion] Addition and subtraction Bu Zhong Yi Qi Decoction combined with SOX regimen in the treatment of advanced gastric cancer can improve TCM symptoms and physical condition of patients, reduce the side effects of chemotherapy and is superior to chemotherapy of simple SOX regimen.