据Masotti等描述,口服一剂3.5mg/kg体重的阿斯匹林,血小板环氧酶只轻微地抑制血管壁前列腺素(PGI_2)的产生。较大剂量的阿斯匹林则使PGI_2的产生明显受抑制。他们认为以此可解释在预防动脉血栓形成的临床试验中,口服较大剂量之阿斯匹林,其效果欠隹是可能的。 Masotti等提出每三天口服阿斯匹林3.5mg/kg- According to Masotti et al., Oral administration of a 3.5 mg / kg body weight of aspirin, platelet cyclooxygenase only slightly inhibits the production of PGI-2. Higher doses of aspirin significantly inhibited PGI2 production. In their opinion, it is possible to explain the effect of oral administration of higher doses of aspirin in clinical trials to prevent arterial thrombosis. Masotti et al proposed that oral aspirin every three days 3.5mg / kg-