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目的：探讨可溶性细胞间粘附分子（ｓＩＣＡＭ－１）和转化生长因子－β１（ＴＧＦ－β１ ）在多发性硬化（ＭＳ）发生、发展中的作用。方法：采用ＥＬＩＳＡ方法，测定了３０ 例ＭＳ患者血清中ｓＩＣＡＭ－１ 和ＴＧＦ－β１ 的水平。结果：与对照组和ＮＩＮＤ组相比，ＭＳ患者血清ＴＧＦ－β１ 水平明显下降（Ｐ＜ ０．０１），而ｓＩＣＡＭ－１ 水平则明显升高（Ｐ＜ ０．０１）。动态观察显示，随着病情的好转，ＴＧＦ－β１ 水平逐渐升高，而ｓＩＣＡＭ－１ 水平则逐渐下降。ＭＳ患者头ＭＲＩ上病灶越大，ｓＩＣＡＭ－１ 水平升高也越明显。结论：血清ＴＧＦ－β１ 和ｓＩＣＡＭ－１的检测对判断ＭＳ患者的病情变化具有重要的临床实用价值
Objective: To investigate the role of soluble intercellular adhesion molecule (sICAM-1) and transforming growth factor-β1 (TGF-β1) in the occurrence and development of multiple sclerosis (MS). Methods: Serum levels of sICAM-1 and TGF-β1 were measured in 30 MS patients by ELISA. Results: Compared with control group and NIND group, serum TGF-β1 level in MS patients decreased significantly (P <0.01), but sICAM-1 level increased significantly (P <0.01). Dynamic observation showed that with the improvement of the disease, the level of TGF-β1 gradually increased while the level of sICAM-1 decreased gradually. The larger the head lesion in MS patients, the more obvious the increase of sICAM-1. Conclusion: The detection of serum TGF-β1 and sICAM-1 has important clinical value in judging the change of MS patients