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目的探讨染色体多态性对体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)助孕患者临床妊娠结局的影响。方法回顾性分析2015年3月—2016年6月在第二军医大学长海医院生殖医学中心首次进行IVF/ICSI-ET周期不孕不育夫妻的临床资料。根据夫妻一方或双方染色体是否存在多态性分为2组:染色体多态性组(夫妻一方或双方存在染色体多态性)和染色体正常组(夫妻双方染色体均正常)。比较分析两组夫妻在IVF/ICSI-ET治疗后的胚胎种植率、临床妊娠率、早期流产率和每移植周期活产率。结果共纳入1 108对行IVF/ICSI-ET助孕的不孕不育夫妻,其中染色体多态性组69对,染色体正常组1 039对。染色体正常组和染色体多态性组的胚胎种植率(34.91%vs 34.62%,P>0.05)、临床妊娠率(49.09%vs 50.72%,P>0.05)、早期流产率(11.37%vs 8.57%,P>0.05)、每移植周期活产率(41.67%vs 43.47%,P>0.05)差异均无统计学意义。结论染色体多态性不影响IVF/ICSI-ET助孕患者的临床结局。
Objective To investigate the effect of chromosome polymorphism on the clinical pregnancy outcome in IVF / ICSI-ET assisted pregnancy in vitro fertilization / intracytoplasmic sperm injection. Methods The clinical data of the first infertile couples with IVF / ICSI-ET cycles in the Reproductive Medicine Center of Changhai Hospital, Second Military Medical University from March 2015 to June 2016 were retrospectively analyzed. According to the existence of polymorphisms in one or both of the spouses, the two groups were divided into two groups: chromosome polymorphism group (chromosome polymorphism in one or both spouses) and normal chromosome group (the chromosomes were normal in both spouses). The rate of embryo implantation, clinical pregnancy rate, early abortion rate and live birth rate per transplant period were compared between the two groups after IVF / ICSI-ET treatment. Results A total of 1 108 pairs of IVF / ICSI-ET infertile couples were enrolled in this study. Among them, 69 pairs were polymorphic and 1 039 pairs were normal chromosomes. The embryo implantation rate (34.91% vs 34.62%, P> 0.05), clinical pregnancy rate (49.09% vs 50.72%, P> 0.05), early miscarriage rate (11.37% vs 8.57% P> 0.05). There was no significant difference in live birth rate per transplant (41.67% vs 43.47%, P> 0.05). Conclusion Chromosomal polymorphism does not affect the clinical outcome of patients with IVF / ICSI-ET pregnancy.