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目的探讨人血清白细胞介素-6(IL-6)与C-反应蛋白(CRP)水平与慢性阻塞性肺疾病(COPD)急性加重期的关系。方法以40例慢性阻塞性肺疾病患者为研究对象,其中急性加重期的28例为试验组,稳定期的12例为对照组,所有研究对象均于入院时及治疗2周后行血清IL-6与CRP水平的检测,同时行肺功能及其他常规化验指标的检查。结果①慢性阻塞性肺疾病患者急性加重期血清中IL-6与CRP水平,治疗后较治疗前显著降低(P<0.01);而稳定期患者IL-6与CRP的水平,治疗前后差异无统计学意义(P>0.05)。②与稳定期相比,急性加重期IL-6与CRP的水平显著升高(P<0.01)。③1秒率(FEV1/FVC)与IL-6及CRP的水平呈负相关。结论血清IL-6与CRP水平随COPD的病情缓解呈进行性下降,IL-6与CRP联合检测可作为早期判断COPD急性加重的敏感指标。
Objective To investigate the relationship between serum interleukin-6 (IL-6) and C-reactive protein (CRP) level and acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Forty patients with chronic obstructive pulmonary disease were enrolled in this study. Among them, 28 patients in the acute exacerbation period were in the experimental group and 12 patients in the stable period were control group. All subjects were on admission and 2 weeks after treatment, serum IL-6 and CRP level of detection, at the same time lung function and other routine laboratory tests. Results ① Serum levels of IL-6 and CRP in acute exacerbation of chronic obstructive pulmonary disease patients were significantly lower than those before treatment (P <0.01), but there was no statistic difference between the levels of IL-6 and CRP in stable patients Significance (P> 0.05). ② Compared with the stable phase, the level of IL-6 and CRP in acute exacerbation increased significantly (P <0.01). The 1 second rate (FEV1 / FVC) was negatively correlated with the levels of IL-6 and CRP. Conclusions Serum levels of IL-6 and CRP decline progressively with the severity of COPD. Combined detection of IL-6 and CRP may be used as a sensitive indicator of acute exacerbation of COPD.