柯兴氏综合征患者在两侧肾上腺全切除或次全切除后出现全身色素沉着,蝶鞍扩大及垂体肿瘤者称为 Nelson 氏综合征。但多发性内分泌腺瘤并行肾上腺切除术后引起的 Nelson 综合征少见报道,现将我院诊治的1例报告如下。患者,女,47岁,1961年发现甲状腺左叶有一块状物并经手术切除,病理证实为毒性甲状腺瘤,术后高代谢症群好转。1964年起患者出现纳亢、肥胖、闭经,且阴毛呈男性分布,诊断为柯兴氏综合征,故行右肾上腺全切除、左肾上腺次全切除术(仅留0.3×2cm 肾上腺组织块且血供尚可),病理切片示肾上腺皮质增生、网状带及束状带分泌亢 Patients with Cushing’s Syndrome have systemic pigmentation after total adrenalectomy or subtotal resection, and sella enlargement and pituitary tumors are referred to as Nelson’s syndrome. However, Nelson syndrome caused by multiple endocrine adenomas following adrenalectomy is rarely reported. One case reported in our hospital is now reported as follows. The patient, female, 47 years old, had a piece of material in the left lobe of the thyroid gland in 1961 and was surgically resected. Histopathology proved to be toxic thyroid tumor, and the postoperative hyperglycemia group improved. Since 1964, the patient developed nausea, obesity, amenorrhea, and the pubic hair was male and was diagnosed as Cushing’s syndrome. Therefore, the right adrenalectomy and subtotal adrenalectomy were performed (only 0.3×2 cm of adrenal tissue was left behind and blood was removed) For Shangke), pathological sections showing adrenocortical hyperplasia, reticular formation, and bundled band secretion