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The genomic mechanism of steroid hormone action has been widely accepted in endocrinology. But there art- difficulties in interpreting the rapid action of steroid hormone on nervous system. The non-genomic mode of glucocorticoid (GC) action was raised in 1987, which proposed that GC acted on the membrane receptor of the neu-non A series of experiments showed that through the non-genomic mechanism, GC could depress the excitability, in-hibit the secretion, and augment the uptake of glutamate of neurons. The effects are mediated by the proposed mem-brane recepror of GC. the existence of which was substantiated by electrophysiological, biochemical, and morphological evidences
The genomic mechanism of steroid hormone action has been been accepted in endocrinology. But there art- difficulties in interpreting the rapid action of steroid hormone on nervous system. The non-genomic mode of glucocorticoid (GC) action was raised in 1987, which proposed that GC acted on the membrane receptor of the neu-non A series of experiments showed that through the non-genomic mechanism, GC could depress the excitability, in-hibit the secretion, and augment the uptake of glutamate of neurons. The effects are mediated by the proposed of which was substantiated by electrophysiological, biochemical, and morphological evidences