论文部分内容阅读
目的观察缬沙坦联用贝那普利治疗高血压合并舒张性心力衰竭的疗效和安全性。方法71例高血压合并舒张性心力衰竭患者随机分为缬沙坦联用贝那普利组(治疗组)和单用贝那普利组(对照组),疗程均为6个月。观察治疗前后两组患者的心功能级别、左室舒张功能、心脏结构、血压及药物不良反应。结果治疗组与对照组心力衰竭改善的总有效率分别为88.9%和58.6%,治疗组疗效优于对照组(P<0.01)。两组治疗前后左室舒张功能、左心房扩大、左心室肥厚、收缩压与舒张压均有明显改善(P<0.05)。结论缬沙坦联用贝那普利治疗高血压合并舒张性心力衰竭有更好的临床疗效,而且是安全的。
Objective To observe the efficacy and safety of valsartan combined with benazepril in the treatment of hypertension and diastolic heart failure. Methods A total of 71 patients with hypertension and diastolic heart failure were randomly divided into two groups: valsartan combined with benazepril group and benazepril alone group (control group) for 6 months. The levels of cardiac function, left ventricular diastolic function, cardiac structure, blood pressure and adverse drug reactions were observed before and after treatment. Results The total effective rate of improvement of heart failure in treatment group and control group were 88.9% and 58.6%, respectively. The curative effect in treatment group was better than that in control group (P <0.01). Before and after treatment, left ventricular diastolic function, left atrial enlargement, left ventricular hypertrophy, systolic and diastolic pressure were significantly improved (P <0.05). Conclusion Valsartan combined with benazepril in the treatment of hypertension with diastolic heart failure have better clinical efficacy, and is safe.