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目的：探讨累及前颅底或颅内脑组织的鼻腔鼻窦癌的手术切除途径及方法。方法：经颅面联合进路行显微外科连续整块切除累及前颅底或颅内脑组织的鼻腔鼻窦癌15例，其中5例仅累及前颅底，10例累及前颅底至颅内额叶脑组织。硬脑膜缺损应用大腿阔筋膜修补。结果：15例均作了术后随访，随访时间最长为10年，最短2年。其中4例为初治患者，11例为综合治疗后局部复发患者。9例无瘤生存2年以上，2年无瘤生存率为60．00％。11例接受此手术行拯救外科治疗，其中6例无瘤生存2年以上，2年拯救成功率为54．55％。结论：经颅面联合进路行显微外科连续整块切除累及前颅底或颅内脑组织的鼻腔鼻窦癌是可行的。
Objective: To investigate the surgical approach and methods of excision of nasal cavity and paranasal sinuses involving the anterior skull base or intracranial brain tissue. METHODS: A total of 15 consecutive cases of nasal sinus cancer involving the anterior skull base or intracranial brain tissue were treated with a craniofacial joint approach. Five cases involved only the anterior skull base, and 10 cases involved the anterior skull base to intracranial. Frontal lobe brain tissue. Dural defect application of thigh fascia repair. Results: All 15 cases were followed up for a maximum of 10 years and a minimum of 2 years. Of these, 4 were initially treated patients and 11 were locally relapsed patients after comprehensive treatment. Nine cases had no tumor survival for more than 2 years, and the 2-year disease-free survival rate was 60.00%. Eleven patients underwent surgical rescue surgery, of which six patients survived for more than two years and the success rate of rescue was 54.55%. Conclusion: It is feasible to perform continuous microsurgical resection of anterior skull base or intracranial brain tissue with nasal cavity and sinus cancer via transcranial approach.