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敏乐血定(Minoxidil)是一种直接作用于血管壁的血管舒张药。由于它的降压作用良好,较肼苯达嗪强,且无严重副作用,因此作者用以治疗常用降压药无效的尿毒症患者。共用于9例有严重高血压及肾功能衰竭患者。除1例外,在研究时所有患者均因处于肾脏疾患末期而接受长期血液透析疗法。患者均为男性,年龄30～48岁(平均40岁)。仰卧位血压为200±6/124±3毫米汞柱。7例在治疗前眼底变为Keith-Wagener-Barker分类第Ⅲ级或第Ⅳ级。6例曾发过心衰。所有患者都有心脏肥大或左室肥大。用敏乐血定之前,这些病人几乎已用过所有常用的降压药,但仍不能控制血压。且出现严重的副作用(主要是体位性低血压)。
Minoxidil is a vasodilator that acts directly on the walls of blood vessels. Because of its good antihypertensive effect, it is more potent than hydralazine and has no serious side effects. Therefore, the authors are used to treat uremic patients who are ineffective with commonly used antihypertensive drugs. Commonly used in 9 patients with severe hypertension and renal failure. All but 1 patients underwent long-term hemodialysis at the end of their kidney disease at study time. Patients were male, aged 30 to 48 years (mean 40 years). Supine blood pressure was 200 ± 6/124 ± 3 mmHg. Seven patients had a Keith-Wagener-Barker class III or IV fundus before treatment. 6 cases had heart failure. All patients had cardiac hypertrophy or left ventricular hypertrophy. Before using Levofloxacin, these patients had used almost all the commonly used antihypertensive drugs, but still could not control their blood pressure. And serious side effects (mainly orthostatic hypotension).