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目的 测 定患 者 地 高 辛血 药 浓 度 ,为 临 床 合理 用 药 提 供参 考 。 方 法 采 用 荧光 偏 振 免 疫 法测 定83例 地 高 辛 血 药 浓 度 ,分 析 血 药 浓 度 与 疗 效 的 关 系 及 其 影 响 因 素 以 及 不 同 给 药 方 案 对 测 定 结 果 的 影 响 。 结果 有 效浓 度 范围 (0.8~2.0 滋g/L)与临 床 表现 并不 完 全一 致,影响 因 素较 多,不同 给药 方 案监 测结 果 差异 较 大。结论 地 高辛 血 药浓 度监 测 必须 密切 结 合临 床,综合 考 虑各 方面 的 因素 ,实 现个 体化 给 药。
Objective To determine the concentration of digoxin in patients with drug for clinical reasonable reference. Methods Fluorescence polarization immunoassay was used to determine the plasma concentration of 83 digoxin. The relationship between plasma concentration and therapeutic effect and its influencing factors were analyzed. The effects of different dosage regimens on the determination results were analyzed. Results The effective concentration range (0.8-2.0 μg / L) was not completely consistent with clinical manifestations, with many influencing factors, and the results of different drug regimens were quite different. Conclusion The monitoring of digoxin plasma concentration must be closely combined with clinical and comprehensive consideration of various factors to achieve individualized administration.