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背景:颈动脉粥样硬化斑块及颈动脉狭窄与脑梗死的发生相关,应用彩色多普勒超声检测定量评估颈动脉粥样硬化的程度可否先期预测脑梗死的发生?目的:探讨脑梗死患者颈动脉粥样硬化以及颈动脉狭窄与脑梗死的关系。设计:以诊断为依据的病例对照研究。地点和对象:研究对象为在佛山市第一人民医院住院的患者,均为佛山市常住居民,年龄23～87岁,其中脑梗死患者148例(脑梗死组),非缺血性心、脑血管疾病患者45例为对照组。方法:对两组患者颈动脉进行彩色多普勒超声检查。主要观察指标:观察两组患者颈总动脉内膜-中层厚度、斑块及狭窄情况。结果:颈总动脉内膜-中层厚度增厚的发生率脑梗死组为76.6%,对照组为15.6%,脑梗死组高于对照组(χ2=40.877,P<0.001);颈动脉粥样硬化斑块的发生率脑梗死组为58.8%,对照组为26.7%,脑梗死组颈动脉粥样硬化斑块的发生率明显高于对照组(χ2=12.99,P<0.001),差异有显著性意义。结论:颈动脉粥样硬化与脑梗死有关,同侧颈动脉粥样硬化斑块形成可能是引起脑梗死的原因之一。
BACKGROUND: Carotid atherosclerosis plaques and carotid artery stenosis are associated with the occurrence of cerebral infarction. Color Doppler echocardiography can quantitatively assess the extent of carotid atherosclerosis. Can we predict the occurrence of cerebral infarction? Objective: Carotid atherosclerosis and carotid artery stenosis and cerebral infarction. Design: A case-control study based on diagnosis. Location and Subjects: The subjects were hospitalized in Foshan First People’s Hospital. All of them were residents of Foshan City, aged from 23 to 87 years old. Among them, 148 cases of cerebral infarction (cerebral infarction group), non-ischemic heart and brain 45 cases of vascular disease in the control group. Methods: Color Doppler echocardiography was performed on carotid artery in two groups. MAIN OUTCOME MEASURES: Intima-media thickness, plaque and stenosis of carotid artery were observed in two groups. Results: The incidence of carotid artery intima - media thickness thickening was 76.6% in cerebral infarction group and 15.6% in control group, higher than that in control group (χ2 = 40.877, P <0.001), carotid atherosclerosis The incidence of plaque was 58.8% in cerebral infarction group and 26.7% in control group. The incidence of carotid atherosclerotic plaques in cerebral infarction group was significantly higher than that in control group (χ2 = 12.99, P <0.001), the difference was significant significance. Conclusion: Carotid atherosclerosis is associated with cerebral infarction. The formation of ipsilateral carotid atherosclerotic plaque may be one of the causes of cerebral infarction.