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磷酸萘酚喹是 4 氨基喹啉类新抗疟药 ,对间日疟和恶性疟具有很好的预防和治疗作用。但在毒理实验中发现 ,该药大剂量时对实验动物肝脏有一定的毒性损害 ,可引起肝细胞脂肪变性和坏死。Ｉ期临床实验中 ,发现个别志愿者血清转氨酶升高。该药在临床上大规模推广应用时 ,如服用不当
Naphthoquine phosphate is a 4 amino quinoline new antimalarial drug against Plasmodium vivax and Plasmodium falciparum has a good preventive and therapeutic effect. However, toxicological experiments found that when the drug at high doses on the liver of experimental animals have some toxic damage, can cause fatty degeneration and necrosis of liver cells. Phase I clinical trials found that individual volunteers elevated serum transaminases. The drug in clinical large-scale promotion and application, such as improper use