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目的:研究西宁地区急性心肌梗死患者血HCY水平及与叶酸、维生素B_(12)的相关性。方法:急性心梗患者分为常规治疗组和干预组。常规治疗组给予常规治疗,分别在治疗前和治疗2周进行血清HCY、叶酸和维生素B_(12)水平检测及对比;干预组在常规治疗基础上给予维生素B_(12)、叶酸口服,分别在治疗前和治疗后2周进行血清HCY、叶酸和维生素B_(12)水平检测及对比;同期选择健康体检者作为对照组,进行血清HCY、叶酸和维生素B_(12)水平检测及对比。结果:急性心梗组人群HCY水平明显高于对照组人群HCY水平,有显著性差异(P<0.01);急性心梗组人群叶酸、维生素B_(12)水平明显低于对照组人群叶酸、维生素B_(12)水平,有显著性差异(P<0.01);急性心梗组中干预组服药前后HCY水平有显著性降低(P<0.01),血清叶酸、维生素B_(12)水平均有显著性增加(P<0.01);常规治疗组治疗前后HCY水平也有降低;血清叶酸、维生素B_(12)水平也有增加,但均较干预组不明显。结论:通过合理补充叶酸与B族维生素,可降低HCY水平,对心血管疾病患者的早期预防与治疗及延缓并发症的发生有重要的临床意义,从而也降低心血管疾病的发生率和病死率。
OBJECTIVE: To study the correlation between serum HCY level and folic acid and vitamin B 12 in patients with acute myocardial infarction in Xining. Methods: Acute myocardial infarction patients were divided into routine treatment group and intervention group. The patients in the conventional treatment group were given routine treatment. The levels of serum HCY, folic acid and vitamin B 12 were detected and compared before treatment and 2 weeks respectively. The intervention group was given vitamin B 12 on the basis of conventional treatment, Serum HCY, folic acid and vitamin B 12 levels were measured and compared before treatment and 2 weeks after treatment. Meanwhile, healthy volunteers were selected as control group to detect and compare serum HCY, folic acid and vitamin B 12 levels. Results: The levels of HCY in acute myocardial infarction group were significantly higher than those in control group (P <0.01). The levels of folic acid and vitamin B 12 in acute myocardial infarction group were significantly lower than those in control group (P <0.01). The levels of HCY in the intervention group before and after treatment were significantly decreased (P <0.01), and the levels of serum folate and vitamin B 12 in the acute myocardial infarction group were significantly higher than those in the control group (P <0.01). The levels of HCY in the conventional treatment group also decreased before and after treatment. The levels of serum folic acid and vitamin B 12 also increased, but both were not significant compared with the intervention group. CONCLUSIONS: HCY levels can be decreased by appropriate folic acid supplementation and B vitamins, which is of important clinical significance for early prevention and treatment of cardiovascular diseases and delay of complications, thus reducing the incidence of cardiovascular diseases and mortality .