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为研究有氧运动和低脂膳食抑制动脉粥样硬化斑块形成的可能机制，本研究探讨了１０周有氧运动和低脂膳食对ＡｐｏＥ基因缺陷小鼠主动脉动脉粥样硬化斑块面积及肝脏ＳＲ－Ｂ１ｍＲＮＡ和蛋白水平的影响。结果表明有氧运动和／或低脂膳食增加ＡｐｏＥ基因缺陷小鼠肝脏ＳＲ－ＢＩ基因及蛋白的表达水平。肝脏ＳＲ－Ｂ１ｍＲＮＡ水平与动脉粥样硬化斑块间存在负相关关系的趋势（相关系数ｒ值为－０．８１４，显著性检验Ｐ值为０．０６２），而且ＳＲ－Ｂ１蛋白水平与动脉粥样硬化斑块间也存在负相关关系（相关系数ｒ值为－０．８７１，显著性检验的Ｐ值为０．０１４）。结果提示在动脉粥样硬化斑块形成过程中，有氧运动和低脂膳食引起的ＳＲ－Ｂ１基因及蛋白表达水平的增加可能是二者具有抗动脉粥样硬化斑块发生作用的潜在机制。
In order to study the possible mechanism of aerobic exercise and low-fat diet inhibiting the formation of atherosclerotic plaque, this study investigated the effects of 10-week aerobic exercise and low-fat diet on the area of aortic atherosclerotic plaque in ApoE- Liver SR-B1 mRNA and protein levels. The results indicate that aerobic exercises and / or low-fat diets increase the expression of SR-BI genes and proteins in the liver of ApoE-deficient mice. There was a negative correlation between liver SR-B1mRNA and atherosclerotic plaque (r = -0.814, P = 0.062). Moreover, the relationship between SR-B1 protein level and atherosclerosis There was also a negative correlation between plaques (r = -0.871, P = 0.014 for significance). The results suggest that during the process of atherosclerotic plaque formation, the increase of SR-B1 gene and protein expression induced by aerobic exercises and low-fat diet may be the underlying mechanism of their anti-atherosclerotic plaque formation.