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目的:观察在胚胎移植前后行经皮穴位电刺激对体外受精-胚胎移植(IVF-ET)者妊娠结局的影响。方法:选取经新鲜周期或复苏周期进行移植的受试者,共1761例,分为观察组(735例)和对照组(1026例)。两组均采用IVF-ET方案移植,观察组在移植前24h和移植当天2h内进行经皮穴位电刺激治疗,选用穴位分别为子宫、血海、地机和中脘、关元、足三里、太溪,两次治疗均为30min;对照组不加用经皮穴位电刺激干预。分别于移植术后14d和4~5周观察两组受试者生化妊娠率及临床妊娠率。结果:观察组生化妊娠率为62.0%(456/735),临床妊娠率为51.2%(376/735),均优于对照组的57.3%(588/1026)、44.9%(461/1026),差异均有统计学意义(均P<0.05)。结论:经皮穴位电刺激可提高体外受精-胚胎移植者妊娠率,可能成为一种安全无痛的新型辅助生育手段。
Objective: To observe the effect of transcutaneous electrical stimulation before and after embryo transfer on pregnancy outcome of IVF-ET. Methods: A total of 1761 subjects who were transplanted in fresh or resuscitation cycles were divided into observation group (735 cases) and control group (1026 cases). The two groups were all transplanted with IVF-ET. The observation group was treated with transcutaneous electrical acupuncture at 24h before transplantation and within 2h after transplantation. The selected acupoints were uterus, blood sea, ground plane and Zhongli, Guanyuan, Zusanli, Too River, two treatments were 30min; control group without the use of electrical acupuncture points intervention. The biochemical pregnancy rates and clinical pregnancy rates of the two groups were observed on the 14th day and the 4th to 5th weeks after the transplantation. Results: The biochemical pregnancy rate in the observation group was 62.0% (456/735) and the clinical pregnancy rate was 51.2% (376/735), which were all better than those in the control group (57.3%, 58.9%, 44.9%, 461/1026) The differences were statistically significant (all P <0.05). Conclusion: Transcutaneous electric acupuncture can improve the pregnancy rate of IVF-ET and may become a new safe and painless method of assisted reproduction.