钩端螺旋体 (简称钩体 )病主要在我国长江流域的省市流行 ,从 6 0年代发现钩体病以来 ,累计发病近 2 4 5 0 0 0 0例 ,病死近 2 5 0 0 0例 ,发病率和病死率都较高 ,危害极大 〔1〕。现使用的钩体浓缩菌苗 ,接种后对控制钩体病流行起到了重要作用 ,但该苗副反应较大 ,免疫效果不 Leptospirosis is endemic in the provinces and cities of the Yangtze River basin in our country. Since the discovery of leptospirosis in the 1960s, the cumulative incidence of Leptospira was 224.5 million and the number of deaths was nearly 25 000. Incidence and mortality are higher, a great harm 〔1〕. Lactobacillus concentrated vaccine is used, the control of leptospirosis after vaccination played an important role in the epidemic, but the vaccine side effects of large, immune effect is not