用电子显微镜观察比较博来霉素A_6和目前临床使用的博来霉素(复合物)对小鼠的肺毒性。博来霉素A_6和博来霉素分别以相当于1/40、1/20和1/10 LD_(50)剂量给小鼠ip 7d或10 d。病变表现为肺毛细血管的损伤,内皮细胞胞浆空泡、皂泡样变、网状化、伪足样突起、血小板粘着和微血栓形成等最为常见。博来霉素A_6引起的肺病变明显地较博来霉素为轻,提示博来霉素A_6有可能成为肺毒性较低的博来霉素类抗癌药物。 The lung toxicity of bleomycin A_6 and currently clinically used bleomycin (complex) to mice was observed by electron microscopy. Bleomycin A_6 and bleomycin were administered to mice ip for 7 d or 10 d at the doses corresponding to 1/40, 1/20 and 1/10 LD50, respectively. Lesions manifested as pulmonary capillary injury, endothelial cell vacuolar cytoplasm, soap bubble change, reticulation, pseudo-foot protuberance, platelet adhesion and microthrombus formation most common. Bleomycin A_6 caused lung lesions significantly more bleomycin than light, suggesting that bleomycin A_6 may become less toxic lung bleomycin anticancer drugs.