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目的:建立电感耦合等离子体质谱(ICP-MS)法快速测定布洛芬注射液中铝、钙、铬、镁、锌、钾、硼、锶、镉、钡、铅、砷、锑、钠、锂15种元素的含量。方法:样品被2%的硝酸溶液稀释后经电感耦合等离子体质谱仪检测,通过在线内标的方式校正基体干扰和漂移。结果:15种元素的方法检出限在0.031~5.1μg·L~(-1),加样回收率在82.6%~107%,RSD小于5%。结论:电感耦合等离子体质谱(ICP-MS)法测定布洛芬注射液中金属元素快速、准确、灵敏度高,可以为布洛芬注射液质量控制提供技术保障。
OBJECTIVE: To establish a rapid and sensitive method for the determination of aluminum, calcium, chromium, magnesium, zinc, potassium, boron, strontium, cadmium, barium, lead, arsenic, antimony, sodium and calcium in ibuprofen injection by inductively coupled plasma mass spectrometry (ICP- The content of 15 elements of lithium. Methods: The samples were diluted with 2% nitric acid solution and detected by inductively coupled plasma mass spectrometry (ICP-MS). The interference and drift of matrix were corrected by online internal standard. Results: The detection limits of the 15 elements were between 0.031 and 5.1 μg · L -1, the recoveries were between 82.6% and 107%, and the RSDs were less than 5%. Conclusion: Determination of metal elements in ibuprofen injection by inductively coupled plasma mass spectrometry (ICP-MS) is rapid, accurate and sensitive. It can provide technical support for the quality control of ibuprofen injection.