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目的探讨成釉细胞瘤(AB)的发病和复发机制。方法对2004—2006年中国医科大学口腔医学院和沈阳市口腔医院病理科存档的34例病理诊断为AB的蜡块标本(滤泡型AB18例,丛状型AB10例,壁性AB6例)及口腔正常黏膜蜡块标本14例,采用SABC法免疫组化检测BMP-2的表达。胞浆出现棕黄色颗粒为阳性着色。用改良打分法半定量分析BMP-2表达。采用秩和检验比较。结果AB与正常口腔黏膜的BMP-2表达差异具有统计学意义。滤泡型AB组、丛状型AB组和壁性AB组间差异无统计学意义。结论BMP-2在AB中有阳性表达。在不同病理类型的AB中,BMP-2的表达差异无统计学意义。BMP-2在AB的发生、发展中起重要作用。
Objective To investigate the pathogenesis and recurrence mechanism of ameloblastoma (AB). Methods From 2004 to 2006, 34 pathological specimens of pathological diagnosis of AB were collected from Department of Stomatology, China Medical University and Stomatology Hospital of Shenyang Medical College (follicles AB 18, plexiform AB, wall AB 6) Oral normal mucosa wax specimens in 14 cases, using immunohistochemical SABC immunohistochemical detection of BMP-2 expression. Cytoplasm brown particles appear positive staining. Semi-quantitative analysis of BMP-2 expression using a modified scoring method. Using rank sum test comparison. Results The difference of BMP-2 expression between AB and normal oral mucosa was statistically significant. Follicular AB group, plexiform AB group and wall AB group no significant difference between groups. Conclusion BMP-2 is positively expressed in AB. The expression of BMP-2 in different pathological types of AB was not statistically different. BMP-2 plays an important role in the occurrence and development of AB.