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晚期卵巢癌对妇科肿瘤学家来说仍然是一难于应付的问题,无疑地是以外科手术为主要手段,尽可能多的切除肿瘤。手术后单一的药物化疗在疾病的早期阶段颇为满意,但在晚期和转移癌的病人效果不佳。为此,作者于7年前开始用新的两种药物联合方法治疗Ⅲ和Ⅳ期卵巢癌病人。研究范围是1971年9月后诊断为Ⅲ和Ⅳ期的病人,约有半数病人转来以前已做过手术并认为不可能再作手术探查。在化疗前要做骨髓、肝、肾功能化验、胸部X片、肝和脾扫描、静脉肾盂造影、钡灌肠和其它必要的检查,要有完整的病史和体格检查,增大的表浅淋巴结活检和胸腹水细胞学检查。环磷酰胺7～8 mg/kg/日共5天,由静脉推入,5-氟脱氧尿苷1.8～2mg/kg/日溶在5%葡萄糖中连续输入共5天。首次化疗后监测病人的副作
Advanced ovarian cancer is still a difficult problem for gynecologic oncologists, undoubtedly surgery as the main means to remove the tumor as much as possible. Single-drug chemotherapy after surgery is quite satisfactory in the early stages of the disease, but is not effective in patients with advanced and metastatic cancers. To this end, the authors began treatment of stage III and IV ovarian cancer patients with a new combination of two drugs seven years ago. The study was performed on patients who were diagnosed as stage III and IV after September 1971. About half of the patients had previously performed surgery and considered it impossible to perform surgical exploration. Before chemotherapy to do bone marrow, liver, kidney function tests, chest X-ray, liver and spleen scan, intravenous pyelography, barium enema and other necessary checks to have a complete history and physical examination, increased superficial lymph node biopsy And ascites cytology. Cyclophosphamide 7-8 mg / kg / day for 5 days, intravenous infusion, 5-fluorodeoxyuridine 1.8 ~ 2mg / kg / day dissolved in 5% glucose for a total of 5 days. After the first chemotherapy to monitor the patient’s side effects