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目的 了解不动杆菌肺炎的临床特征 ,总结治疗经验。方法 对 2 1例不动杆菌肺炎患者的临床特征、病原菌的构成、药敏资料及预后进行回顾性分析。结果 不动杆菌肺炎多见于老年、有慢性基础病且住院时间较长患者 ;病原菌多为鲍曼氏不动杆菌 ,药敏试验显示仅对依米配能、氨基糖甙类抗生素、特美汀有较好的敏感性 ,对其他抗生素如头孢三嗪、头孢噻肟、氧哌嗪青霉素、环丙沙星、头孢哌酮多呈耐药状态 ,对头孢他啶亦相当一部分不敏感或仅中度敏感 ;临床表现缺乏特异性 ,但若患者出现氧合能力下降 ,中至高热 ,白细胞不升高而中性粒细胞升高 ,使用三代头孢菌素、氟喹诺酮类抗菌药 ,抗革兰氏阳性球菌抗生素治疗无效时要注意本病的可能。结论 本病预后较差 ,死亡率较高 ,尤其是有重复使用糖皮质激素史 ,出现持续性氧合能力下降病例预后不良。
Objective To understand the clinical features of Acinetobacter pneumonia and summarize the experience of treatment. Methods The clinical features of 21 cases of Acinetobacter pneumonia, pathogenic bacteria, drug susceptibility data and prognosis were retrospectively analyzed. Results Acinetobacter pneumonia more common in elderly patients with chronic basic diseases and hospitalization longer; pathogen mostly Acinetobacter baumannii, susceptibility testing showed that only according to meter with the energy, aminoglycoside antibiotics, Has a good sensitivity to other antibiotics such as cefotaxime, cefotaxime, piperacillin penicillin, ciprofloxacin, cefoperazone mostly resistant to ceftazidime a considerable part of the non-sensitive or only moderately sensitive ; The clinical manifestations of the lack of specificity, but if patients with decreased oxygenation, moderate to high fever, leukocytes does not increase and neutrophils increased, the use of third-generation cephalosporins, fluoroquinolones antibacterials, Gram-positive cocci Antibiotic treatment ineffective pay attention to the possibility of this disease. Conclusion The prognosis of this disease is poor, the mortality rate is higher, especially the history of repeated use of glucocorticoids, sustained decline in oxygenation ability of patients with poor prognosis.