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目的:探讨国产米非司酮配伍前列腺素抗早孕效果的影响因素。方法:将500例分为两组,一组用米非司酮25mg,每日2次,连服3d,第4天上午阴道塞卡前列腺素栓(15-甲基PGF_(2a)酸)1mg(简称卡前列素栓组)。另一组米非司酮的用法及剂量与前一组同,第4天上午口服米索前列醇0.6mg(简称米索组)。结果:米索组完全流产率为93.2%,明显高于卡前列素栓组的88.4%(P<0.05)。米索组的流产效果受服药者年龄、既往人工流产次数、用药前胚囊平均直径与血β-hCG水平的影响较卡前列素栓组小。结论:米非司酮配伍米索前列醇是方便、有效、副作用小的抗早孕方法。用药后2w测定β-hCG值结合B超检查可用于监测药物流产效果,有实用价值。
Objective: To investigate the influencing factors of anti-pregnancy effect of domestic mifepristone combined with prostaglandin. Methods: 500 cases were divided into two groups, one group with mifepristone 25mg, twice a day, and even served 3d, the morning of the fourth day vaginal plug prostaglandin suppository (15-methyl PGF_ (2a) acid) 1mg (Abbreviation card prostaglandin suppository group). Another group of mifepristone usage and dose with the former group, the morning of the 4th day of oral misoprostol 0.6mg (referred to as misoprostol). Results: The complete miscarriage rate was 93.2% in the misoprostol group, which was significantly higher than that in the cardoprost group (88.4%, P <0.05). The misoprostol effect of misoprostol was less affected by the age of the attending physician, the number of previous induced abortions, the mean diameter of the embryo sac before administration, and the blood β-hCG level than that of the carboprost suppository group. Conclusion: Mifepristone combined with misoprostol is a convenient, effective and anti-premature pregnancy method with small side effects. 2w determination of β-hCG after treatment combined with B-ultrasound can be used to monitor the effect of medical abortion, and has practical value.