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目的探讨儿童Kaup指数与胰岛素抵抗现象的相关性。方法对300例儿童常规测量身高、体重并测定空腹血糖、空腹胰岛素,分别计算其Kaup指数及胰岛素抵抗指数,按照Kaup指数分为消瘦组、正常组、超重组、肥胖组,进行相关性分析及组间比较。结果各组IR指数随Kaup指数增大而依次增大,且两者均呈正相关性关系,其相关性肥胖组>超重组>正常组>消瘦组;超重组和肥胖组的IR指数明显高于消瘦组和正常组,差异有统计学意义(均P<0.01);在超重组和肥胖组中,IR指数与Kaup指数的相关性具有统计学意义(P<0.05)。结论儿童胰岛素抵抗现象可随其体重的增加而增强,Kaup指数可作为儿童胰岛素抵抗的重要预测因子。
Objective To investigate the correlation between Kaup index and insulin resistance in children. Methods 300 children were routinely surveyed with height and weight, and fasting blood glucose and fasting insulin were measured. Kaup index and insulin resistance index were calculated respectively. According to Kaup index, they were divided into emaciation group, normal group, overweight group and obesity group Comparison between groups. Results The IR index of each group increased with the increase of Kaup index, and both of them had a positive correlation, the correlation obesity group> overweight group> normal group> weight loss group; IR index of overweight group and obesity group was significantly higher than that of obesity group (P <0.01). The correlation between IR index and Kaup index was statistically significant (P <0.05) in overweight group and obesity group. Conclusion Children’s insulin resistance may be increased with the increase of their body weight. Kaup index may be used as an important predictor of insulin resistance in children.