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本实验选用三种含铁粉尘(纯氧化铁尘、电焊烟尘及铁锈尘),给大鼠气管内注入染尘,动物于染尘后1、3、6和9个月分别处死,在光镜和透射电镜下观察不同粉尘的致肺纤维化能力。结果表明,纯氧化铁尘可引起肺轻度纤维组织增生,电焊烟尘和铁锈尘的致肺纤维化能力较纯氧化铁尘明显,但远较石英尘为弱。作者认为含铁粉尘能引起轻度的肺纤维化,而粉尘中的锰、铬等金属成分的存在可能增强了其致纤维化能力。
The experiment selected three kinds of iron-containing dust (pure iron oxide dust, welding dust and rust dust), rats were injected with tracheal dust, the animals were dyed 1,3,6 and 9 months after the death were executed, in the light microscope And the transmission electron microscopy of different dust induced pulmonary fibrosis. The results showed that pure iron oxide dust can cause mild lung fibrosis, electrical welding dust and rust-induced pulmonary fibrosis than pure iron oxide dust, but far weaker than the quartz dust. The authors believe that iron-containing dust can cause mild pulmonary fibrosis, while the presence of metal components such as manganese and chromium in the dust may enhance its ability to cause fibrosis.