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细胞周期蛋白依赖激酶抑制因子(CKI)是细胞周期调控网络的主要成员之一,在周期调控中具有重要的地位,CIP-KIP是CKI两个家族之一,与细胞生长分化和肿瘤发生方面有极其重要的关系。本文对CIP-KIP家族的细胞周期调控、基因敲除以及促CDK/CychnD装配功能的最新进展进行综述。
Cyclin-dependent kinase inhibitor (CKI) is one of the major members of the cell cycle regulatory network and plays an important role in the regulation of the cycle. CIP-KIP is one of the two families of CKI, which is related to cell growth and differentiation and tumorigenesis Extremely important relationship. This review summarizes the recent advances in the CIP-KIP family of cell cycle regulators, gene knockouts and the promotion of CDK / CychnD assembly.