论文部分内容阅读
目的考察复方肝素口服结肠靶向胶囊对大鼠溃疡性结肠炎(ulcerative colitis,UC)的治疗作用。方法将大鼠随机分为模型组,正常对照组,阳性对照组,辅料对照组,复方肝素高、低剂量组共6组。其中除正常对照组外,其余5组均采用三硝基苯磺酸造模。连续灌胃给药12 d后,从组织损伤评分、髓过氧化物酶(myeloperioxidase,MPO)活性、肠道微生态的变化3方面对复方制剂的药效进行考察。结果与模型组相比,复方肝素高剂量组结肠部位炎性损伤明显好转(P<0.01),MPO水平明显降低(P<0.01),肠道有益菌显著增加,有害菌明显降低。结论复方肝素口服结肠靶向制剂对大鼠溃疡性结肠炎有较好的抗炎及改善肠道微生态的作用。
Objective To investigate the therapeutic effect of oral administration of heparin on colon ulcerative colitis (UC) in rats. Methods The rats were randomly divided into 6 groups: model group, normal control group, positive control group, adjuvant control group, high and low heparin heparin group. In addition to the normal control group, the other five groups were used trinitrobenzene sulfonic acid modeling. After 12 days of continuous intragastric administration, the efficacy of the compound preparations was investigated in terms of tissue damage score, myeloperioxidase (MPO) activity and intestinal microecology. Results Compared with the model group, the inflammatory injury in the high dose heparin group was significantly improved (P <0.01), the MPO level was significantly decreased (P <0.01), the beneficial bacteria in the intestine was significantly increased, and the harmful bacteria was significantly decreased. Conclusion The oral administration of Heparin heparin-induced colon ulcer colitis rats have better anti-inflammatory and improve intestinal microecology.