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目的探讨早期介入认知行为治疗对重度抑郁发作患者生活质量的影响。方法选取60例重度抑郁发作患者,随机分为干预组和对照组,各30例。对照组给予常规药物治疗、护理和健康教育,干预组在对照组的基础上早期进行6周的认知行为治疗。在基线、第4周、第6周采用汉密尔顿抑郁量表、健康状况调查问卷进行评定。结果抑郁量表及健康状况调查问卷各维度评分在基线组间比较,差异无统计学意义(P>0.05)。重复测量的方差分析结果显示,抑郁量表及健康状况调查问卷各维度评分时间主效应有统计学意义(P<0.05)。抑郁量表及健康状况调查问卷的7个维度(心理健康维度除外)评分组间主效应有统计学意义(P<0.05)。结论重度抑郁发作患者早期给予认知行为治疗,可明显改善患者的抑郁情绪,提高其生活质量。
Objective To investigate the effect of early interventional cognitive behavioral therapy on quality of life in patients with major depressive episode. Methods Sixty patients with major depressive episode were randomly divided into intervention group and control group, with 30 cases in each group. The control group was given routine drug treatment, nursing and health education. The intervention group was treated with cognitive behavioral therapy for 6 weeks on the basis of the control group. At baseline, week 4, week 6, the Hamilton Depression Inventory and the Health Questionnaire were used for assessment. Results There was no significant difference in scores of all dimensions between the depression scale and the health status questionnaire among the baseline groups (P> 0.05). Repeated measures ANOVA showed that the major effect of the scale of depression scale and health status questionnaire was statistically significant (P <0.05). There were significant differences among the seven dimensions (except the mental health dimension) of the depression scale and the health status questionnaire (P <0.05). Conclusions Cognitive and behavioral therapy in patients with major depressive episode may improve the depression and improve their quality of life significantly.