Dysregulation of the Wnt pathway has been extensively studied in multiple diseases,including some angiogenic disorders.Wnt signaling activation is a major stimulator in pathological angiogenesis and thus,Wnt antagonists are believed to have therapeutic potential for neovascular disorders.Actually,some Wnt antagonists have been identified directly from the anti-angiogenic factor family.This review summarizes the recent progress toward understanding of the roles of Wnt pathway antagonists in angiogenic regulation and their mechanism of action,and exploring their therapeutic potential.