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目的观察硫酸链霉素局部注射对三叉神经分支的组织学影响。方法应用大耳白兔局部注射链霉素，通过光、电镜观察其三叉神经的病理改变。结果动物局部注射链霉素后，三叉神经的神经纤维发生空泡变性、炎细胞浸润，严重者发生坏死。结论链霉素治疗三叉神经痛的机制，可能是通过破坏神经纤维髓鞘，抑制其产生异位冲动，从而达到临床治疗的效果。
Objective To observe the histological effects of streptomycin sulfate on the trigeminal nerve branches. Methods The rabbits were injected with streptomycin locally and the pathological changes of the trigeminal nerve were observed by light and electron microscope. Results After streptomycin was injected into animals, the nerve fibers of trigeminal nerve were vacuolar degeneration and infiltration of inflammatory cells. In severe cases, necrosis occurred. Conclusion The mechanism of streptomycin in the treatment of trigeminal neuralgia may be through the destruction of nerve fiber myelin sheath, inhibition of its ectopic impulse, so as to achieve the effect of clinical treatment.