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通过体外和体内实验研究中研Ⅱ号抗猴免疫缺陷病毒 (SIV)感染作用和免疫调节作用 ,结果表明 :中研Ⅱ号在体外缺乏直接的抗SIV感染作用 ;而体内实验显示中研Ⅱ号对SIV感染所致的猴艾滋病模型免疫系统的功能状态具有一定的调节作用 ,表现为抑制感染早期异常的免疫细胞活化 ,促进晚期抑制状态的免疫细胞活化 ,对不同感染时期的免疫功能呈双相调节作用。中研Ⅱ号通过对细胞功能紊乱的调节实现其免疫保护作用 ,这可能是其治疗艾滋病的药理基础
In vitro and in vivo experiments were conducted to investigate the infection and immunoregulatory effects of Zhongyan II anti-monkey immunodeficiency virus (SIV). The results showed that Zhongyan No. 2 lacked direct anti-SIV infection in vitro; in vivo experiments showed that Sinopharm II had SIV infection. The functional status of the immune system of the monkey AIDS model has a certain regulatory effect, which is to inhibit the activation of abnormal immune cells in the early stage of infection, promote the activation of immune cells in the late suppression state, and show biphasic regulation of immune function in different infection periods. China Research Institute No. 2 achieves its immunoprotective effect through the regulation of cell dysfunction, which may be the pharmacological basis for its treatment of AIDS.